Search results for "Acyclic nucleoside"

showing 2 items of 2 documents

Transfer of aciclovir from plasma to human breast milk.

2011

Aciclovir (CAS 59277-89-3) is frequently used in herpes simplex virus diseases, but administration to lactating women occurs only rarely. Therefore, information about the pharmacokinetics of aciclovir in human breast milk is limited. The concentration in breast milk is 2 to 3 fold increased compared to plasma. The reason for this increase is unknown until now. An active transport mechanism has been assumed. The aim of this study was to prove whether the higher concentration of aciclovir in human breast milk is due to only a passive transfer. Two chambers separated by a semipermeable membrane were used. The first chamber contained plasma with aciclovir, the second chamber breast milk without…

AdultMilk HumanChemistryAcyclic nucleosidevirus diseasesHuman metabolismAcyclovirPharmacologyBreast milkmedicine.disease_causeAntiviral AgentsDiffusionHerpes simplex virusPharmacokineticsDrug DiscoveryBlood plasmaImmunologymedicineHumansFemaleAciclovirHuman breast milkmedicine.drugArzneimittel-Forschung
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Acyclovir treatment in 2 patients with benign trigeminal sensory neuropathy

2001

AdultMaleHerpesvirus 3 Humanmedicine.medical_specialtymedicine.medical_treatmentAcyclovirAdministration OralNeurological disorderAntibodies ViralAntiviral AgentsHypesthesiamedicineHumansSimplexvirusAciclovirTrigeminal nerveChemotherapybusiness.industryAcyclic nucleosideHypoesthesiamedicine.diseaseDermatologySurgeryPeripheral neuropathyOtorhinolaryngologyTrigeminal Nerve DiseasesImmunoglobulin GSensory neuropathyFemaleSurgeryOral Surgerymedicine.symptombusinessFollow-Up Studiesmedicine.drugJournal of Oral and Maxillofacial Surgery
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